Relationship between timed 25-foot walk and diffusion tensor imaging in multiple sclerosis
نویسندگان
چکیده
منابع مشابه
Relationship between timed 25-foot walk and diffusion tensor imaging in multiple sclerosis
OBJECTIVE/BACKGROUND The majority of multiple sclerosis patients experience impaired walking ability, which impacts quality of life. Timed 25-foot walk is commonly used to gauge gait impairment but results can be broadly variable. Objective biological markers that correlate closely with patients' disability are needed. Diffusion tensor imaging, quantifying fiber tract integrity, might provide s...
متن کاملEvaluation of the relationship between axon injury and clinical symptoms in patients with multiple sclerosis using diffusion tensor MRI imaging
Background: Magnetic resonance imaging (MRI) is a non-invasive imaging technology that shows detailed anatomical and pathological images. It is often used for disease detection, diagnosis, and treatment monitoring, in particular with neurodegenerative diseases, such as Multiple sclerosis (MS), Alzheimer's and amyotrophic lateral sclerosis. However, conventional MRI provides only qualitative inf...
متن کاملValidity of the timed 25-foot walk as an ambulatory performance outcome measure for multiple sclerosis
The Multiple Sclerosis Outcome Assessments Consortium (MSOAC) includes representatives from advocacy organizations, Food and Drug Administration (FDA), European Medicines Agency (EMA), National Institute of Neurological Disorders and Stroke (NINDS), academic institutions, and industry partners along with persons living with multiple sclerosis (MS). One of the MSOAC goals is acceptance and quali...
متن کاملThe clinical meaning of walking speed as measured by the timed 25-foot walk in patients with multiple sclerosis.
IMPORTANCE Walking impairment, a common clinical manifestation of multiple sclerosis (MS), is often measured in clinical practice and clinical trials using the Timed 25-Foot Walk (T25-FW). OBJECTIVE To evaluate the relationship between walking speed measured by the T25-FW and the Physical Component Summary (PCS) score of the 36-Item Short Form Health Survey (SF-36) to better understand the cl...
متن کاملDiffusion tensor magnetic resonance imaging in multiple sclerosis.
OBJECTIVES To quantify, using diffusion tensor imaging (DTI), the tissue damage in lesions and normal-appearing white matter (NAWM) from a large cohort of patients with MS and to investigate the magnitude of the correlation between DTI-derived metrics and clinical disability. METHODS Dual-echo and DTI scans were obtained from 78 patients with relapsing-remitting, secondary progressive, or pri...
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ژورنال
عنوان ژورنال: Multiple Sclerosis Journal - Experimental, Translational and Clinical
سال: 2016
ISSN: 2055-2173,2055-2173
DOI: 10.1177/2055217316655365